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SARS-CoV-2 and all subgenomic RNAs are enriched in the host mitochondria, and viral genomes 5 - and 3 -UTRs contain distinct mitochondrial localization signals [61], indicating that the viral RNA may hijack the mitochondria, an interesting hypothesis for experimental validation [61]

The microsomal system, on the other hand (active CYP2E1), stimulates the generation of ROS, notably superoxide and hydroxyl radicals, resulting in oxidative stress and cell death

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