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and (ii) delivery-related issues, as PLGA nanoparticles require further engineering to achieve high selectivity and specificity, overcome BBB restrictions, and effectively target pathological sites, and/or multi-targeting strategies may be necessary as AD exhibits multiple pathological targets (Lu et al., 2023)

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Management of acute cholangitis is based on the grade of disease severity that is usually classified as severe, moderate, and mild (Figure 3)

Perrone A, Giovino A, Benny J, Martinelli F (2020) Advanced glycation end products (AGEs): biochemistry, signaling, analytical methods, and epigenetic effects

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Unfortunately, many people who experience this injury have ongoing deficits in their function and quality of life