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Furthermore, coagulation disorders, present in COVID-19 patients, increase neuroinflammation, stroke, and cognitive decline risks (Pezzini and Padovani 2020)

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Of note, GFAP is produced by activated astroglia that release ROS and pro-inflammatory mediators, creating a vicious cycle between oxidative stress and inflammation and hence playing a vital role in neuroinflammation with its subsequent neuronal apoptosis and hence neuronal damage (Colombo and Farina 2016)