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4.2 Targeting mtROS to improve tumor immunotherapy Since ROS in tumor cell mitochondria have been shown to play an important role in immunotherapy, how mitochondrial targeted drugs can promote tumor cells to produce excessive ROS, damage mtDNA, release immunogenic intracellular substrates, and activate anti-tumor immunity are important areas of focus in anti-tumor research ( Figure 9 )

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This phase delay is consistent with the delay induced by application of glutamate to SCN slices, suggesting that copper chelation may increase NMDAR activity, consistent with studies demonstrating copper-induced inhibition of NMDAR currents (Trombley & Shepherd, 1996

Furthermore, it actively shifts the body's melanin production away from eumelanin (dark brown/black pigments) toward pheomelanin (lighter pigments)

However, the evidence is limited and mixed, so patients should avoid assuming it will reliably improve deep sleep

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