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This phosphorylation modification acts as a brake signal, inhibiting the activity of eIF2 and significantly reducing global protein synthesis to maintain cell survival, (Harding et al., 2003)

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Others are included in the synthesis and activation of thyroid hormones, e.g., iodothyronine deiodinase (DIO) 13, synthesis of selenoproteins, e.g., selenophosphate synthetase 2 (SPS2/SEPHS2), or transport of Se (e.g., selenoprotein P) (39, 40)

Cancer 129 , 741753 (2023)

Randomized open-label trial of semaglutide and dapagliflozin in patients with type 2 diabetes of different pathophysiology