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Regarding specific mechanisms, Wang et al

As body weight decreases, basal metabolic rate naturally declines because there is less body mass to maintain

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[DOI] [PMC free article] [PubMed] [Google Scholar] 36.Kitzman DW, Upadhya B, Vasu S
In order to qualify for Semaglutide or other peptide, your BMI must be 27% or higher