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Enhanced mevalonate pathway signaling by mutant p53 promotes the activity of YAP and PDZ-binding motif (TAZ) proto-oncogenes [176], whereas the oncogenic activity of YAP is dependent on ZMYND8-mediated cholesterol biosynthesis [177]

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Pharmacological treatments, however, have shown limited evidence of effectiveness in alleviating fatigue

the prolongevity effect of rifampicin has been previously reported 30
