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Two oxygens interact directly with each calcium, leading the third oxygen away from the binding site in vitro

41 In a randomized controlled trial in 162 couples with male infertility undergoing in vitro fertilization, those given 15 mg folic acid per day for three months had better outcomes than those given placebo: 44.1% of couples receiving folic acid were able to conceive and 35.6% had a viable pregnancy detectable on ultrasound at seven weeks of gestation compared with 22.4% and 20.4%, respectively, in those receiving placebo

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Oldfield BJ, Gleeson B, Morford KL, et al

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Durkee, S