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and Socha, K

Vitamin C is essential for collagen synthesis

Supplementing with this is a very effective treatment for B12 deficiencies commonly found in patients who suffer from diseases or have nutritional deficits (such as ultra low calorie diets)

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This evidence was strengthened by studies in vivo in which manipulation of calpastatin levels, an endogenous calpain inhibitor, led to modulation of the neurological phenotype seen in a SCA3 mouse model, as well as of mutant ATXN3 aggregation and neurodegeneration, consistent with a role for calpain activation in pathogenesis [50, 52]

What Should Researchers Look For