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Dissociative anesthetics (ketamine and nitrous oxide) impair glutamatergic neurotransmission and mitochondrial function, contributing to excitotoxicity and neurodegeneration

For example, cellular senescence, classified as an antagonistic/secondary hallmark of aging, results as a consequence of persistent DNA and/or proteomic damage (primary hallmarks) that drives integrative hallmarks such as chronic inflammation and altered intracellular signaling, which further perpetuate other aging hallmarks

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Epidural steroid and NSAID injections are done on an outpatient basis

This makes it ideal for use in medical settings where contamination could be an issue