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In response to SASP, macrophages are recruited into the articular space and secrete proinflammatory factors to activate synovial fibroblasts, which promote osteophyte formation and further exacerbating osteoarthritis [140]

10.1039/D0FO02375B 85 KongX.-J.LiuJ.LiuK.KohM.ShermanH.LiuS.et al (2021)

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Biochem Biophys Rep 34:103544 Imanparast F, Mashayekhi FJ, Kamankesh F, Rafiei F, Mohaghegh P, Alimoradian A (2020) Improving endothelial dysfunction in type 2 diabetes with chromium and vitamin D3 by reducing homocysteine and oxidative stress: a randomized placebo-controlled trial

Some patients develop hemolytic anemia and severely affected patients often develop major neurologic disorders and seizures