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Metformin also has indirect anti-tumour effects by reducing insulin and insulin-like growth factor 1 levels, which promote tumour growth and proliferation
Haferlach C, et al
Another study was undertaken to test the anti-inflammatory activity of shionone in a rat model
KPT-330 is known to affect tumor suppressor genes and transcription factors such as p53 through nuclear accumulation of p53 and prevention of MDM2/4 related degradation 43
2025 Jul 30;16(1):6996
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