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In line with that, Superoxide dismutase 1 ( Sod1) knockout mice and mice expressing mutated Sod1 exhibit increased PC in sciatic nerve and skeletal muscle, respectively ( Gpx4 haploinsufficient mice fed a high fat-high sucrose diet exhibit increased 4-HNE adducts in liver and heart ( The second line of defense involves direct detoxification of free RLAs by specialized phase I and II metabolic enzymes ( +/ NAD(P)H cofactors to oxidize RLAs to their corresponding acids or reduce them to alcohol

[DOI] [PMC free article] [PubMed] [Google Scholar] 94.Paradies G, Petrosillo G, Paradies V, Ruggiero FM

It improves skin texture and tone

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