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doi: 10.3389/fimmu.2021.775526 284 ZhengZ.WangS.WuC.CaoY.GuQ.ZhuY.et al

Leyane et al., 2022) Specific endogenous proteins and environmental contaminants can induce microglia to become too active and generate ROS, which can be neurotoxic (Afsheen et al., 2022) A growing body of evidence suggests that activation of various enzymes, such as NOX2 in microglia, is neurotoxic not only by producing extracellular ROS that harm nearby neurons but also by commencing redox signaling in microglia that intensifies the pro-inflammatory response (Pajares et al., 2020

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SAM is required for methylation reactions including histone methylation and DNA methylation, in which it donates a methyl group and becomes S-adenosylhomocysteine (SAH)