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Activation of mGluRs induces protein kinase C (PKC) phosphorylation and upregulates NMDAR function, leading to an increase in Ca 2+ influx, which acts as a pervasive and pluripotent second messenger ( 2+ triggers a cascade of reactions within cells to activate protein kinases, phosphatases, and nitric oxide synthase (NOS)

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Oct 2021;88(10):673-685