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A subset of these affects the childhood population, and has historically been interpreted as malignant, although current evidence and outcome data suggests they represent benign entities

Materials and Methods Chemicals and standards LC grade solvents and common chemicals (ACS grade) were purchased from Sigma-Aldrich (Munich, Germany) and Fisher Scientific (Schwerte, Germany)

Several studies have indicated that although the neutralization of both toxins was necessary for the maximum protection of rodents, the neutralization of TcdB alone seemed to be adequate for mammals, which suggested that the neutralization effect may depend on host species (Leav et al., 2010

10.1128/JB.01439-13 60

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