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Intestinal flora and disease mutually shape the regional immune system in the intestinal tract

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Studies with human CYP enzymes determined that several can metabolise APAP to NAPQI, the most important of which are CYP1A2, CYP2E1 and CYP3A4.15,16 These studies were later extended17 to demonstrate that, at high concentrations of APAP, metabolism via CYP2E1 predominates