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Argani P, Lal P, Hutchinson B, Lui MY, Reuter VE, Ladanyi M

(New York, N.Y.) 350, 13751378

We revealed that DAF-16 activation is an important factor that mediates the extended lifespan of the glp-1(-) and fem-3(-) mutants, and its forced activation can reverse the shortened lifespan of the mog-3(-) mutant

These effects are centrally mediated and not dependent on hormonal replacement mechanisms

Immunometabolic profiling of T cells from patients with relapsing-remitting multiple sclerosis reveals an impairment in glycolysis and mitochondrial respiration
