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As pleiotropic signaling molecules (Dimitrow 2009), they have been implicated in the regulation of neuronal function and thus may play a role in the pathogenesis of AD

10.1080/10408390701425615 24 EsterasN.AbramovA

For all longitudinal analyses, we used generalized estimating equations to adjust standard errors to account for the correlation of observations within individuals, with the working covariance structure being first-order autoregressive for the models where time was a continuous variable and independence for the models where time was a categorical variable

As previously discussed, the EOS of AUD individuals is characterized by increased PDYN because of methylation at particular SNPs in the PDYN promoter, which promotes anxiogenesis ( Pdyn and Pnoc promoters in the amygdala of treated rats compared to controls

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Insulin resistance (IR) refers to the reduced sensitivity and reactivity of insulin target organs (liver, adipose tissue and skeletal muscle) to endogenous or exogenous insulin, resulting in lower glucose uptake and utilization than normal (Haas et al., 2016)