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doi: 10.1016/j.drup.2019.100647 318 GuKJLiG

TRPV4 inhibition prevents increased water diffusion and blood-retina barrier breakdown in the retina of streptozotocin-induced diabetic mice

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In Drosophila , mutation of any of the Sod s leads to ROS sensitivity and a shortened lifespan, so there has been a major effort by several laboratories to determine whether overexpression of SODs could be beneficial for lifespan