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doi: 10.1530/eje.0.1470077 154 PalaNALawayBAMisgarRADarRA

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Classically activated (M1) macrophages are usually induced by lipopolysaccharide (LPS) or interferon- (IFN-) and are characterized by high iNOS expression and increased secretion of pro-inflammatory factors such as tumor necrosis factor- (TNF-), interleukin-1 (IL-1), and interleukin-6 (IL-6)

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