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Docking simulations were conducted following AutoDock Vina protocol, with a grid box specifically encompassing the taxane-binding site of -tubulin

The crystal of the possible target proteins was obtained from a PDB

It is conceived that the as-constructed ZMTP nanosheet can catalytically scavenge intracellular ROS of M1 macrophages to favor their polarization toward anti-inflammatory M2 macrophages, finally benefiting the treatment of rheumatoid arthritis