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NAD + /NADH ratios reflect redox status and play an integral part in the ETC, with NADH being the primary electron donor

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The oxidation of Cys thiols leads to the formation of sulfenic acid (RSOH), which can react with other reactive sulfur species to form mixed disulfides (RSSR) with protein thiols, S -glutathione adducts (RSSG) with glutathione, or persulfides (RSSH) with hydrogen sulfide (Willems et al