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Lancet 366 , 18621867 (2005)
Forbes and Thorburn 2018)
Patients reported significant, life-altering improvements in working memory, focus, organizational skills, and the ability to multitask
Recently, SLC1A3, as a crucial effector of p53, has been shown to support cell survival and growth in the absence of glutamine 149
Their dysfunction rewires cardiac metabolism: for instance, endothelial VDAC downregulation in atherosclerosis shifts fatty acid utilization toward lipotoxicity, while MCU hyperactivity in hypertension drives calcium overload-induced vascular hypertrophy [15,16]
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