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Recently, treatment with curcumin revealed the inhibition of p300 HAT activity, leading to a decreased acetylation of pro-nociceptive proteins (BDNF and Cox-2) in neuropathic pain in mice model (Zhu et al., 2014)

CGA at a concentration of 40 g/mL (112.90 M) clears over 70% of DPPH (1,1-diphenyl-2-picrylhydrazyl radical) free radicals in vitro , and at 25 M, it reduces reactive oxygen species (ROS) to alleviate oxidative stress in intestinal cells ( eucommia , honeysuckle , and green tea ( The liver is vital for metabolism, the endocrine regulation, and immune response but is often exposed to irritants like viruses, medications, and chemicals (Wang et al., 2024)

Various studies have also reported that ERmitochondrial contact plays important role in the biogenesis of mitochondrial-derived compartments [197,198,199], and these compartments might play vital roles in cellular adaptation to environmental stress conditions [199]