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This has been extensively reported with three randomised studies (Table 2) [45,46,47] and one trial [46] also had a three year follow up study [48]
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In patients with severe liver disease, portal blood bypassing the liver leads to increased levels of ammonia and other toxic substances in the blood, which can lead to complications such as brain damage, sarcopenia and muscle spasticity [204]
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Lenalidomide plus dexamethasone for high risk smoldering multiple myeloma
