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Changes in insulin sensitivity induced by short-term growth hormone (GH) and insulin-like growth factor I (IGF-I) treatment in GH-deficient adults are not associated with changes in adiponectin levels

The overall quality of evidence for this outcome was low due to serious imprecision (low number of trials and participants)

H., Borchelt, D

Finally, we emphasize the need for further studies to address these issues, provide insight into the mechanisms of action of functional food active ingredients, and validate their clinical efficacy, with a view to better translating them into effective strategies for cancer prevention and treatment

Kwak M-K, Itoh K, Yamamoto M, Kensler TW (2002) Enhanced expression of the transcription factor Nrf2 by cancer chemopreventive agents: role of antioxidant response element-like sequences in the nrf2 promoter

(48) highlighted that lower intake of vitamin K2 leads to the accumulation of inactive MGP (dp-ucMGP) and is associated with increased arterial stiffness, vascular calcification, and heart failure