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(2020) Adaptation of the master antioxidant response connects metabolism, lifespan and feather development pathways in birds, Nat
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People with the MTHFR gene variants can absorb all sorts of folate including folic acid

However, mechanism does not automatically determine timing

Acetyl-L-carnitine (ALCAR) for the prevention of chemotherapy-induced peripheral neuropathy in patients with relapsed or refractory multiple myeloma treated with bortezomib, doxorubicin and low-dose dexamethasone: a study from the Wisconsin Oncology Network

Reference Benekos, Kissoudis, Nianiou-Obeidat, Labrou, Madesis, Kalamaki, Makris and Tsaftaris2010
