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Nanofiber mat delivery systems represent the cutting edge, with studies showing that these mats significantly enhance mucosal permeability by increasing local drug concentration and providing close, sustained contact with the mucosa

Nature 477 , 225228 (2011)

[DOI] [PMC free article] [PubMed] [Google Scholar] 286.Maciel AA, Oria RB, Braga-Neto MB, Braga AB, Carvalho EB, Lucena HB, Brito GA, Guerrant RL, Lima AA

It is noteworthy that -Syn is also localized in mitochondria-associated endoplasmic reticulum membranes (MAMs), which are contact sites between two organelles, the mitochondria and the endoplasmic reticulum (Guardia-Laguarta et al., 2014)

it affects about half of patients, according to the John Hopkins Lupus Center

Drug-induced QT interval shortening following antiepileptic treatment with oral rufinamide