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2020;21(21):p

Also, while doing a surrogate study, I am seeing people use nitrosamines as surrogates

When studying specific pathways, you must be certain the effects youre observing are from the target molecule alone

Structure and function of lipopolysaccharide binding protein

Among the numerous partners that interact with NRF2 regulating its activity, two members of the CNC-bZIP protein family BTB and CNC homolog 1 (BACH1) and BTB and CNC homolog 2 (BACH2) are two negative regulators of NRF2: they compete with NRF2 for the binding to ARE sequences of target genes, thereby preventing the production of antioxidant enzymes and cellular defense against toxicity [232, 233]
Moreover, GSTM2 inhibits hepatic steatosis by affecting the capability to detoxify and function as an antioxidant
