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In vitro drug release studies in simulated intestinal fluid (SIF) and gastric fluids (SGF) revealed that over 80% of the two drugs were released within 5 h in SGF, with a sustained release observed up to 24 h in SIF

This reduces the leaf internal CO 2 , which leads to the formation of ROS such as hydroxyl radicals (OH) singlet oxygen ( 1 O 2 ), hydrogen peroxide (H 2 O 2 ), alkoxyl radical (RO) and superoxide radical (O 2 ) mainly by enhancing electrons leakage to oxygen molecule 1,2,3,4

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