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Description
Copper overload triggers apoptosis Apoptosis, a type of programmed cell death, is marked by substantial alterations in cell morphology and the activation of specific caspase and mitochondrial control pathways (130)

Preclinical: With increased knowledge of the nose-brain pathway and IN therapeutics, IN-BDNF to mouse models of depression is being explored: in a chronic mild stress (CMS) induced-depression model, mice were given AAV-packaged BDNF fused with cell-penetrating peptides, human immunodeficiency virus-1 transactivator of transcription (TAT), and influenza A hemagglutinin glycoprotein 2 (HA2)

This approach leverages the rich blood supply in nasal tissue to enable faster uptake into the circulation
Endocr Connect 13(5)
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doi: 10.1007/s40200-021-00965-2 47
