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When the catalytic cleft opens, R516 is rotated down on to the phosphates of ADP

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Such insights could pave the way for novel microbiota-based therapeutic approaches to improve reproductive health and overall quality of life for women affected by these conditions

Upon irradiation with 660 nm red light, local ROS generation is induced, leading to rapid cleavage of the TK bond and release of the DOX prodrug for locally activated chemotherapy (Fig