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This was the first randomized, placebo-controlled trial with methyl B 12 and autism

3.2.3 FUNDC1 mediated mitophagy The FUN14 domain-containing protein 1 (FUNDC1) is widely present on the mitochondrial outer membrane and acts as a regulator of mitochondrial autophagy in response to hypoxia, inducing Parkin-independent mitophagy (Liu et al., 2012)

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Most patients stay on a combined protocol for at least three to six months to experience optimal results