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Set7/9 was shown to upregulate CCL2 through H3K3 methylation of the promoter region
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While a significant proportion (~30%) of children with NF1 may have osteopenia [4], there is insufficient data to suggest that this leads to an increased fracture risk or should be tested for or treated
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Where indicated, lysates were incubated additionally with DTT (10100 mM, Sigma) for 1 h at 37 C before electrophoresis
