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In general, the majority of the CD38 NADase catalytic activity will generate nicotinamide, and a nearly stoichiometric amount of ADPR with residual amounts of NAD being converted to cADPR and nicotinamide [34-35, 38-40, 58-60]

Presently, isatuximab is approved for the treatment of RRMM in combined therapy with pomalidomide and dexamethasone [79] and, in patients who have undergone two prior therapies, in combination with carfilzomib and dexamethasone [80]