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Therefore, biosynthesis and metabolism of VD are under the control of VD regulatory genes (GC/ VDBP /VD-25-hydroxylase) in the liver, while the downstream actions of the active 1,25(OH) 2 VD in muscle are mediated by glucose metabolism genes ( VDR /peroxisome proliferator-activated receptor gamma coactivator 1-alpha [ PGC-1 ]/glucose transporter type 4 [ GLUT-4 ])

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What are the challenges and potential methods for developing targeted therapies that modulate lipid-regulated autophagy pathways without causing significant off-target effects

In the TME, multiple factors contribute to immune suppression, including low oxygen and pH levels, limited nutrient availability (e.g., glucose, fatty acids, and amino acids), accumulation of immunosuppressive metabolites (e.g., ROS, lactate, and lipids), and increased secretion of immunosuppressive cytokines as well as chemokines [6,7,8]

The effect of curcumin on the cadmium-induced mitochondrial apoptosis pathway by metallothionein 2A regulation

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