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Presented atthe joint American Academy of Child and Adolescent Psychiatry/Canadian Academy of Child and Adolescent Psychiatry Joint Annual Meeting: Toronto, Canada

Carnitine has been trialed in cases of sepsis and found to retard protein loss without affecting protein metabolism in target tissues [94]

(a) Concentration-dependence of Pde9a induction following 24-h exogenous propionate treatment in NRVMs in vitro

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11 Although low concentrations of PPA may be beneficial, humans with impairments in PPA metabolism (that is, propionic or methymalonic acidemia, holocarboxylase, biotinidase or B12 deficiency, valproate or ethanol exposure) exhibit neurodevelopmental conditions with behavioral and biochemical similarities to ASD