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doi: 10.1126/science.125.3249.648

Molecular analysis covering mutation hotspots and gene fusions/gene skipping was carried out with either Ion AmpliSeq TM V2 Lung/Colon cancer panel (Thermo) or Archer Fusion Plex Lung Panel (ArcherDX) or by using targeted Idylla BRAF, KRAS and EGFR mutation kits (Biocartis)

4 Prospect In-depth study of GPX family members has helped to discover not only the function of individual GPXs, but also the function of hydroperoxides as mediators in redox regulation

Hydroperoxide isomerization generates hydroxy-epoxides and keto-epoxides

Characterized by their unpaired electron(s), superoxide radicals, hydroxyl radicals, hydrogen peroxide, nitric oxide, lipid alkoxyl and peroxyl radicals are the most common reactive oxygen species in living, aerobic systems[2]

Ferroptosis, a form of regulated cell death initiated by lipid peroxidation, differs from other types of cell deaths at genetic, biochemical, and morphological levels 24,25