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Several GLS inhibitors have been developed, among which CB-839 is currently undergoing clinical trials as a potent, orally bioavailable GLS-selective inhibitor for the treatment of various cancers, including TNBC, NSCLC, and colon cancer (NCT03057600, NCT03057600, NCT03057600, NCT03057600, NCT03057600, NCT03057600)

Compared to HCs, 103 metabolites were elevated but 123 were declined in the R group ( Figure 2F )

[DOI] [PubMed] [Google Scholar] 107.Takeuchi M, Kimura S, Kuroda J, et al

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* Correspondence: Grgory Bouchaud [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Thus, GPX1 and Bcl-2 display analogous effects on an antioxidative event in the signalling cascade leading to inhibition of apoptosis, although by different mechanisms