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For example, it is well established that fat accumulation is associated with OxS at the systemic level, which is mainly due to a decrease in antioxidant enzymes and an increase in fatty acids in adipocytes, due to the activation of the pro-oxidant enzyme nicotinamide adenine dinucleotide phosphate reduced form (NADPH) oxidase [218], which is involved in the formation of ROS [219]

Moreover, curcumin has been proposed to mitigate the vascular complications of diabetes, including diabetic retinopathy, cardiomyopathy, and diabetic nephropathy (484, 485)

Individual responses vary based on the specific compounding formulation, injection site, and each patients metabolic baseline

doi: 10.1186/s12943-024-01999-9 212 HendricksJMDoubravskyCEWehriELiZRobertsMADeolKKet al

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