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In a study focusing on triazole analogs as selective COX-2 inhibitors, a comparative molecular field investigation was conducted to explore the SAR, and pharmacophores with effective anti-inflammatory properties were identified

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2 Ketoconazole and itraconazole, best absorbed in an acidic environment, can be affected by drugs that increase gastric pH, such as antacids, histamine (H 2 ) receptor blockers, and proton pump inhibitors

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