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Because BCAAs, such as valine, leucine, and isoleucine, are absorbed in the peripheral tissue, patients with cirrhosis have a lower concentration of the BCAAs and a higher concentration of the aromatic amino acids in the blood compared with healthy people

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Early studies suggested that carnitine supplementation at 24 g/d could directly lower the respiratory quotient, thereby prolonging exercise time and increasing critical exercise intensity, with a recommended dose of 2 g/d

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Moderate treatment of TMAO (6.7 mg/kg) was found to decrease diastolic dysfunction while increasing the TMAO level by four to five times in a hypertensive rat model (Huc et al., 2018)

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Plasma proprotein convertase subtilisin kexin type 9 is not altered in subjects with impaired glucose metabolism and type 2 diabetes mellitus, but its relationship with non-HDL cholesterol and apolipoprotein B may be modified by type 2 diabetes mellitus: The CODAM study

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