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(Removed: "drug") Santus P, Corsico A, Solidoro P, Braido F, Di Marco F, Scichilone N
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An in vitro study revealed that AGEs binding to RAGE on macrophages and microglia promote oxidative stress by activating NF-KB, and MAPK, c-Jun N-terminal kinase (JNK), and p21RAS signaling pathways (197)
In addition to pyroptosis, when hypertensive state exists alone in rats, caspase 3-mediated apoptosis, beclin-1/LC3-II-mediated autophagy, may also decrease the expression of NO and endothelial NOS in the penis, and finally affect the penile vascular endothelium through multiple pathways [120]
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