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BK channels are a product of the KCNMA1 ( Slo1 ) gene and its orthologs (e.g., d Slo in Drosophila ), and are ubiquitously expressed in the CNS

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While youre not likely to run into MPTP (unless youre taking synthetic street drugs), it is chemically similar to a commonly used herbicide called paraquat.[ref] Subsequently, a number of studies have shown that higher paraquat exposure increases the risk of Parkinsons disease.[ref] Monoamine Oxidase increases ROS: When monoamine oxidase breaks down a monoamine (neurotransmitters, tyramine, etc.), the reaction produces hydrogen peroxide and possibly ammonia, which are reactive oxygen species (ROS)

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Rahman MBA, Azaman RN, Omar EM, Latif MAM, Abdulmalek E (2019) Candida rugosa lipase immobilized on diethylaminoethyl-cellulose (deae) for esterification of butyl oleate