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The relationships between different cell types allow for paracrine modulation which, in turn, regulates CNS homeostasis, such as BBB permeability and blood flow (Zlokovic, 2008

Its anti-seizure effects could be attributed to both AMPK-dependent and AMPK-independent mechanisms [75,76]

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Multi-Targeted Therapeutic Strategies Development of inhibitors targeting distinct pathways (e.g., apoptosis inhibitor Emricasan, ferroptosis inhibitor Ferrostatin-1), autophagy modulators (rapamycin), gene therapies (GBA1 restoration), and metal chelators (deferoxamine), alongside antioxidants (N-acetylcysteine) and glial modulators to alleviate neuroinflammation

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Absorption and Effectiveness TB-500 Nasal Spray: Nasal spray offers the convenience of drug delivery to the brain via the cribriform plate from the nostrils, allowing direct access, as well as facilitating systemic absorption through local blood vessels for broader effects throughout the body