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We report the crystal structure of SHARP SPOC in complex with CTD and identify the molecular determinants for its specific binding to phosphorylated serine-5

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doi: 10.3389/fmed.2026.1810363 Received 13 February 2026 Revised 18 March 2026 Accepted 23 March 2026 Published 04 May 2026 Volume 13 - 2026 Edited by Ramona Cioboata, University of Medicine and Pharmacy of Craiova, Romania Reviewed by Robert Steven Wallis, The Aurum Institute, South Africa Giuseppe Castaldo, University of Naples Federico II, Italy Updates Copyright 2026 Barne, Shevade, Bhattacharyya, Christopher, Nair, Abhyankar, Halder, Vora, Khanna, Swarnakar, Chhajed, Santhalingam, Nair and Salvi

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