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2.2 Lipid peroxidation and PUFA susceptibility Lipid peroxidation of polyunsaturated fatty acids (PUFAs), particularly within phospholipid membranes, is a defining feature of ferroptosis ( Key enzymes regulate the synthesis and incorporation of PUFAs into membrane phospholipids

For a research protocol using a localized approach, the injection would typically be subcutaneous or shallow intramuscular

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12 Similarly, in our primary mouse hepatocyte assay, Nrf2 was downregulated in erastin-induced ferroptosis, and tBHQ stimulated Nrf2 to combat ferroptosis, implying that the Nrf2 signaling pathway was involved in the regulation of ferroptosis and that COX-2 affected this regulation

Paz-Linares, A