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Early life adversity, for instance, maternal separation, favors oxidative stress in parvalbumin- (PV-) positive neurons [119] (more on the role of parvalbumin-expressing neurons is discussed further)

This study suggested that depletion of TMX2 using single guide (sg) RNA in K562 cells and mouse primary cortical neurons was sufficient to suppress PR 20 induced cellular toxicity (Kramer et al., 2018)

however, it repressed SLC7A11 expression and induced ferroptosis ( 4KR ), which lacked the ability to repress SLC7A11 expression and thus could not suppress tumor formation

The inhibition of the Na + /H + antiporter (NHE1) for the purpose of intracellular pHi reduction and apoptosis induction via 5-HMA and other amiloride derivatives in leukemia and hepatocarcinoma cells [121-123] The inhibition of carbonic anhydrase (CA) via acetazolamide [124], sulphonamides [80,81], coumarins, thiocoumarins or hydroxycinnamic acids [125,126]

This mechanism is relevant to neuropathy because NF-kB-driven inflammation is a central mediator of nerve damage in diabetic neuropathy, autoimmune neuropathies, and chemotherapy-induced peripheral neuropathy