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Using liquid chromatography-mass spectrometry, levels of L-carnitine and associated metabolites: -butyrobetaine (GBB), crotonobetaine, as well as acylcarnitines, were evaluated at 10-, 25-, and 50-weeks, in the brain and the periphery, in a targeted replacement mouse model of human APOE (APOE-TR)

doi: 10.1016/j.cmet.2012.12.011 50 MaJPazosIMGaiF

Assessment Protocol The testing protocol used in the present investigation is consistent with that previously described by these investigators (Jacobs, 2009)

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Arch Neurol